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Oral medication that should NOT be crushed or opened

Drug delivery systems have become increasingly complex. Some tablets and capsules may have special coatings for example ‘sugar coating’, ‘film coating’ or ‘enteric coating’. These coatings are designed to modify the rate that the drug is released into the body. Thus, it is important to understand the mechanism as well as the rationale before deciding whether it is safe or appropriate to crush tablets or open capsules.[1]

The tablets and capsules with the following words/letters in their names should never be crushed, opened, chewed or sucked.[2]

Word/letterType of product
CR/ChronoControlled Release
EC/EN Enteric Coated
LA  Long Acting
MR/Retard/Slow/ContinuousModified Release
SA  Sustained Action
SR/Dur/Dural Sustained Release
XL Extended Release

The information below details some common examples of tablets and capsules where advice on crushing or opening should be sought prior to manipulation. In these examples, an alternative formulation, such as a liquid medicine, may be a more appropriate option for patients with swallowing difficulties.[1]

Modified release medicines

Frequently identifiable by two letters such as M/R, LA, SA, CR, XL or SR at the end of the name. Words such as “Retard”, “Slow” or “Continuous” in the title are sometimes used instead. These medicines are designed to be released over a prolonged period, the mechanism for slowing absorption may be damaged if the medication is manipulated.[2]

Damage of a modified release medication may result in the whole dose being released quicker than intended. This results in the patient experiencing a period where the drug concentration is too high, causing toxicity, followed by a period where the drug concentration is too low to be therapeutically active meaning that the underlying condition is not being effectively treated.[1]

Enteric coated medicines

Usually identifiable by the two letters EN or EC at the end of the name.[2] These medicines have a special coating on the outside which doesn’t dissolve in stomach acid. This may be to protect the stomach from the drug, protect the drug from the stomach acid or to target the release of the drug past the stomach.[1] Crushing enteric coatings may result in the drug being released too early, being destroyed by stomach acid, or irritating the stomach lining.[3]

Film or sugar-coated medicines

Disruption of the film or sugar coating on a drug may result in rapid degradation of the active ingredient and may also cause skin irritation in patients or carers.[2] Crushing these tablets therefore may not seriously affect how the drug is released but may cause the resultant mixture to be unpleasant to taste which is likely to negatively affect adherence.[1]

Hormonal, cytotoxic or steroidal medicines

Any alteration of a solid-dose oral formulation should be considered under Control of Substances Hazardous to Health (COSHH) regulations since there may be an increased exposure to chemical components. This is of particular importance with hormonal, cytotoxic or steroidal medications. If the tablet is crushed, the drug may go into the air and the dose inadvertently be received by the administrating nurse or carer.[2]

Rosemont Pharmaceuticals supports the knowledge of healthcare professionals concerning patients with swallowing difficulties. Please register for an account to view more information about our portfolio of liquid medicines or view our range of educational resources.

Alternatively, get in touch with us if you would like to speak to someone regarding our products.

ROS000057-004 Aug 2023


  1. Medicines Management and Older People- a guide for healthcare professionals. Edited by R Greenwall. August 2016.
  2. Wright D, Chapman N, Foundling-Miah M et al. Consensus guideline on the medication management of adults with swallowing difficulties. In: Foord-Kelcey G, editor. Guidelines – summarising clinical guidelines for primary care. 30th ed. Berkhamsted: Medendium Group Publishing Ltd; October 2006.
  3. The Royal Pharmaceutical Society. Pharmaceutical Issues when Crushing, Opening or Splitting Oral Dosage Forms June 2011. Available at: https://www.rpharms.com/Portals/0/RPS%20document%20library/Open%20access/Support/toolkit/pharmaceuticalissuesdosageforms-%282%29.pdf (Accessed Aug 2023)